The change index of quantitative electroencephalography for evaluating the prognosis of large hemispheric infarction

Jia Tian; Li-Dou Liu; Yi Zhou; Zhe Zhang; Yue-Hua Pu; Da-Cheng Liu; Li Guo

doi:10.31083/j.jin2002033

The change index of quantitative electroencephalography for evaluating the prognosis of large hemispheric infarction

J Integr Neurosci. 2021 Jun 30;20(2):341-347. doi: 10.31083/j.jin2002033.

Authors

Jia Tian¹, Li-Dou Liu¹, Yi Zhou¹, Zhe Zhang², Yue-Hua Pu², Da-Cheng Liu³, Li Guo⁴

Affiliations

¹ Neurocritical care unit, Department of Neurology, the Second Hospital of Hebei Medical University, 05000 Shijiazhuang, Hebei, China.
² Neurocritical care unit, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 100050 Beijing, China.
³ Capital Medical University, Beijing Tiantan Hospital, 100050 Beijing, China.
⁴ Department of Neurology, the Second Hospital of Hebei Medical University, 050000 Shijiazhuang, Hebei, China.

PMID: 34258932
DOI: 10.31083/j.jin2002033

Abstract

A growing number of studies have demonstrated the role of quantitative electroencephalography in assessing brain function in neuro-intensive care units. Still, few studies have examined patients with large hemisphere infarction. Thirty patients with large hemisphere infarction were included in this preliminary study, and the patients were divided into the death group (twelve patients) and survival group (eighteen patients). Electroencephalography monitored the patients, and a computerized tomography inspection was performed. The quantitative electroencephalography of the alpha-beta/delta-theta ratio change index was calculated and used to predict the prognosis of early large hemisphere infarction patients. The relationship between three months modified Rankin Scale, and alpha-beta/delta-theta ratio change index was analyzed. The death group had negative changes for alpha-beta/delta-theta ratio change index (-0.0140 ± 0.0193), while there was an opposite trend in the survival group, the median is 0.004 (-0.0067, 0.0137). The death group's brain function decreased more severely and rapidly than the survival group (P = 0.004). The highest diagnostic value (AUC value 0.815, P < 0.001) was observed when the alpha-beta/delta-theta ratio change index dropped and exceeded -0.008. The area under the GCS curve was 0.674, but its predictive ability was low (P = 0.094). The correlation analysis result showed that the 3-month modified Rankin Scale was negatively correlated with the alpha-beta/delta-theta ratio change index (r = -0.489, P = 0.006). The alpha-beta/delta-theta ratio change index is considered an indicator for predicting the prognosis of large hemisphere infarction. Therefore, the alpha-beta/delta-theta ratio change index may be a reliable quantitative EEG parameter that predicts the early prognosis of patients with acute large hemispheric infarction.

Keywords: Acute phase; Alpha-beta/delta-theta ratio; Change index; Large hemispheric infarction; Prognosis; Quantitative electroencephalogram.

MeSH terms

Aged
Brain Waves / physiology*
Cerebral Infarction / diagnosis*
Cerebral Infarction / physiopathology*
Electroencephalography / methods
Electroencephalography / standards*
Female
Humans
Male
Middle Aged
Prognosis
Severity of Illness Index

Grants and funding

20190529/Youth Science and Technology Project of Hebei