CytomegaloVirusDb: Multi-omics knowledge database for cytomegaloviruses

Taimoor Khan; Abbas Khan; Syed Nouman Nasir; Sajjad Ahmad; Syed Shujait Ali; Dong-Qing Wei

doi:10.1016/j.compbiomed.2021.104563

CytomegaloVirusDb: Multi-omics knowledge database for cytomegaloviruses

Comput Biol Med. 2021 Aug:135:104563. doi: 10.1016/j.compbiomed.2021.104563. Epub 2021 Jun 9.

Authors

Taimoor Khan¹, Abbas Khan¹, Syed Nouman Nasir², Sajjad Ahmad³, Syed Shujait Ali⁴, Dong-Qing Wei⁵

Affiliations

¹ Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, PR China.
² National Center for Bioinformatics, Quaid-i-Azam University, Islamabad, Pakistan.
³ Department of Health and Biological Sciences, Abasyn University, Peshawar, 25000, Pakistan.
⁴ Center for Biotechnology and Microbiology, University of Swat, Swat, KP, Pakistan.
⁵ Department of Bioinformatics and Biological Statistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, PR China; State Key Laboratory of Microbial Metabolism, Shanghai-Islamabad-Belgrade Joint Innovation Center on Antibacterial Resistances, Joint Laboratory of International Cooperation in Metabolic and Developmental Sciences, Ministry of Education and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200030, PR China; Peng Cheng Laboratory, Vanke Cloud City Phase I Building 8, Xili Street, Nashan District, Shenzhen, Guangdong, 518055, PR China. Electronic address: dqwei@sjtu.edu.cn.

PMID: 34256256
DOI: 10.1016/j.compbiomed.2021.104563

Abstract

Cytomegalovirus infection is a significant health concern and need further exploration in immunologic response mechanisms during primary and reactivated CMV infection. In this work, we evaluated the whole genomes and proteomes of different CMV species and developed an integrated open-access platform, CytomegaloVirusDb, a multi-Omics knowledge database for Cytomegaloviruses. The resource is categorized into the main sections "Genomics," "Proteomics," "Immune response," and "Therapeutics,". The database is annotated with the list of all CMV species included in the study, and available information is freely accessible at http://www.cmvdb.dqweilab-sjtu.com/index.php. Various parameters used in the analysis for each section were primarily based on the whole genome or proteome of each specie. The platform provided datasets are open to access for researchers to obtain CMV species-specific information. This will help further to explore the dynamics of CMV-specific immune response and therapeutics. This platform is a useful resource to aid in advancing research against Cytomegaloviruses.

Keywords: Cytomegalovirus; Database; Immunotherapeutic; Therapeutics; miRNA; siRNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cytomegalovirus* / genetics
Databases, Genetic
Genome
Genomics*
Proteomics