Arrest of root caries with an adjuvant chlorhexidine-fluoride varnish over a 12-months observation period: a QLF-analyzed, placebo-controlled, randomized, clinical trial (RCT)

Odontology. 2022 Jan;110(1):193-202. doi: 10.1007/s10266-021-00637-w. Epub 2021 Jul 13.

Abstract

This study aimed at evaluating the effectiveness of an adjuvant chlorhexidine-fluoride varnish (Cervitec F) for prevention and arrest of root caries on elderly participants using quantitative light-induced fluorescence (QLF). 23 participants with two or three non-cavitated root carious lesions were included and assigned to three groups of different varnishes (CF: Cervitec F, P: placebo, DP: Duraphate). Agents were applied once to root surface at baseline and in follow-up after 3, 6 and 9 months. The lesions were assessed clinically and with QLF. QLF-images were analyzed regarding fluorescence loss (ΔF), lesion volume (ΔQ) and bacterial activity (ΔR) before (t0), after 14 days (t1), 6- (t2) and 12-months (t3). CF showed a significant difference between t0 and t3: ∆F (- 12.51 [15.41] vs. - 7.80 [16.72], p = 0.012), ∆Q (- 2339.97 (20,898.30) vs. - 751.82 (5725.35), p < 0.001), ∆R (23.80 [41.70] vs. 7.07 [37.50], p = 0.006). Independently of the varnish application, preventive care seems positively influence the root caries progress. Although within CF group the strongest effect was observed, no superiority of a specific varnish application was confirmed over a 12-months QLF observation period. Extra topical fluoride can help remineralise dentin lesions and QLF can be used as a measurement method to determine changes in the dentin lesions.

Keywords: Chlorhexidine–fluoride varnish; Clinical trial; Quantitative light-induced fluorescence; Root caries.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Cariostatic Agents
  • Chlorhexidine
  • Dental Caries* / drug therapy
  • Dental Caries* / prevention & control
  • Fluorides
  • Fluorides, Topical
  • Humans
  • Quantitative Light-Induced Fluorescence*
  • Root Caries* / drug therapy
  • Root Caries* / prevention & control

Substances

  • Cariostatic Agents
  • Fluorides, Topical
  • Fluorides
  • Chlorhexidine