A review on the role of chemokines in the pathogenesis of systemic lupus erythematosus

Abstract

Chemokines are a group of cytokines with low molecular weight that principally direct chemotaxis of target cells. They have prominent roles in the pathogenesis systemic lupus erythematosus (SLE) and related complications particularly lupus nephritis. These molecules not only induce autoimmune responses in the organs of patients, but also can amplify the induced inflammatory responses. Although chemokine family has at least 46 identified members, the role of a number of these molecules have been more clarified in SLE patients or animal models of this disorder. In the current paper, we review the role of CCL2, CCL3, CCL4, CCL11, CCL20, CXCL1, CXCL2, CXCL8, CXCL10, CXCL12 and CXCL13 in the pathogenesis of SLE.

Keywords: CCL11; CCL2; CCL20; CCL3; CCL4; CXCL1; CXCL10; CXCL12; CXCL13; CXCL2; CXCL8; Chemokines; Systemic lupus erythematosus.