The biological function of IGF2BPs and their role in tumorigenesis

Invest New Drugs. 2021 Dec;39(6):1682-1693. doi: 10.1007/s10637-021-01148-9. Epub 2021 Jul 12.

Abstract

The insulin-like growth factor-2 mRNA-binding proteins (IGF2BPs) pertain to a highly conservative RNA-binding family that works as a post-transcriptional fine-tuner for target transcripts. Emerging evidence suggests that IGF2BPs regulate RNA processing and metabolism, including stability, translation, and localization, and are involved in various cellular functions and pathophysiologies. In this review, we summarize the roles and molecular mechanisms of IGF2BPs in cancer development and progression. We mainly discuss the functional relevance of IGF2BPs in embryo development, neurogenesis, metabolism, RNA processing, and tumorigenesis. Understanding IGF2BPs role in tumor progression will provide new insight into cancer pathophysiology.

Keywords: Cancer; IGF2BPs; RBPs; RNA processing.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinogenesis / pathology*
  • Embryonic Development / physiology
  • Energy Metabolism / physiology
  • Humans
  • Insulin-Like Growth Factor II / metabolism*
  • Neoplasms / physiopathology
  • Neurogenesis / physiology
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / metabolism*

Substances

  • RNA, Messenger
  • RNA-Binding Proteins
  • Insulin-Like Growth Factor II