Acellular Cartilage Repair Technique Based on Ultrapurified Alginate Gel Implantation for Advanced Capitellar Osteochondritis Dissecans

Daisuke Momma; Tomohiro Onodera; Daisuke Kawamura; Atsushi Urita; Yuichiro Matsui; Rikiya Baba; Tadanao Funakoshi; Makoto Kondo; Toshiya Endo; Eiji Kondo; Norimasa Iwasaki

doi:10.1177/2325967121989676

Acellular Cartilage Repair Technique Based on Ultrapurified Alginate Gel Implantation for Advanced Capitellar Osteochondritis Dissecans

Orthop J Sports Med. 2021 Mar 11;9(3):2325967121989676. doi: 10.1177/2325967121989676. eCollection 2021 Mar.

Authors

Affiliations

¹ Center for Sports Medicine, Hokkaido University Hospital, Sapporo, Japan.
² Faculty of Medicine and Graduate School of Medicine, Department of Orthopaedic Surgery, Hokkaido University, Sapporo, Japan.
³ Keiyu Orthopaedic Hospital, Tatebayashi, Japan.
⁴ Hokkaido Orthopaedic Memorial Hospital, Sapporo, Japan.
⁵ Mochida Pharmaceutical Co Ltd, Tokyo, Japan.

Abstract

Background: One of the most important limitations of osteochondral autograft transplant is the adverse effect on donor sites in the knee. Ultrapurified alginate (UPAL) gel is a novel biomaterial that enhances hyaline-like cartilage repair for articular defects. To avoid the need for knee cartilage autografting when treating osteochondritis dissecans (OCD) of the capitellum, we developed a surgical procedure involving a bone marrow stimulation technique (BMST) augmented by implantation of UPAL gel.

Hypothesis: BMST augmented by UPAL gel implantation improves the cartilage repair capacity and provides satisfactory clinical outcomes in OCD of the capitellum.

Study design: Case series; Level of evidence, 4.

Methods: A total of 5 athletes with advanced capitellar OCD in the dominant elbow underwent BMST augmented by implantation of UPAL gel. The osteochondral defects were filled with UPAL gel after BMST. At a mean follow-up of 97 weeks, all patients were evaluated clinically and radiographically.

Results: At final follow-up, all 5 patients had returned to competitive-level sports, and 4 patients were free from elbow pain. The mean Timmerman-Andrews score significantly improved from 100 to 194 points. Radiographically, all patients exhibited graft incorporation and a normal contour of the subchondral cortex. Magnetic resonance imaging showed that the preoperative heterogeneity of the lesion had disappeared, and the signal intensity had returned to normal. Arthroscopic examinations consistently exhibited improvement in the International Cartilage Regeneration and Joint Preservation Society (ICRS) grade of lesions from 3 or 4 to 1 or 2 in 4 patients at 85 weeks postoperatively. Histologic analysis of biopsy specimens revealed an average total ICRS Visual Assessment Scale II histologic score of 1060.

Conclusion: The acellular cartilage repair technique using UPAL gel for advanced capitellar OCD provided satisfactory clinical and radiographic results. The present results suggest that this novel technique is a useful, minimally invasive approach for treating cartilaginous lesions in athletes.

Keywords: biomaterial; capitellar osteochondritis dissecans; elbow; ultrapurified alginate gel.