Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application

Keshavananda Prabhu C P; Manjunatha Nemakal; Muthumuni Managa; Tebello Nyokong; Lokesh Koodlur Sannegowda

doi:10.3389/fchem.2021.647331

Symmetrically Substituted Zn and Al Phthalocyanines and Polymers for Photodynamic Therapy Application

Front Chem. 2021 Jun 24:9:647331. doi: 10.3389/fchem.2021.647331. eCollection 2021.

Authors

Keshavananda Prabhu C P¹, Manjunatha Nemakal¹, Muthumuni Managa², Tebello Nyokong², Lokesh Koodlur Sannegowda¹

Affiliations

¹ Department of Studies in Chemistry, Vijayanagara Sri Krishnadevaraya University, Ballari, India.
² Department of Chemistry, Institute for Nanotechnology Innovation, Rhodes University, Makhanda, South Africa.

Abstract

N4 macrocyclic complexes of Al and Zn phthalocyanines with symmetrical imine and imidazole moiety at the periphery were synthesized. The synthesized ligands, complexes, and polymers were purified and characterized to study the structure of the molecule. These synthesized complexes were used for photodynamic therapy application as the diamagnetic Zn and Al have the ability to produce and stabilize singlet oxygen species. The synthesized N4 molecules of aluminum iminomethoxy phenyl phthalocyanine and aluminum ethyl phenyl benzimidazolephthalocyanine showed better activity against MCF-7 cells. These results suggest that this assay may be used as an early biomarker of clinical response.

Keywords: infrared spectra; photodynamic therapy; phthalocyanine; quantum yield; singlet oxygen.