Imaging Inflammation - From Whole Body Imaging to Cellular Resolution

Tuula Peñate Medina; Jan Philip Kolb; Gereon Hüttmann; Robert Huber; Oula Peñate Medina; Linh Ha; Patricia Ulloa; Naomi Larsen; Arianna Ferrari; Magdalena Rafecas; Mark Ellrichmann; Mariya S Pravdivtseva; Mariia Anikeeva; Jana Humbert; Marcus Both; Jennifer E Hundt; Jan-Bernd Hövener

doi:10.3389/fimmu.2021.692222

Imaging Inflammation - From Whole Body Imaging to Cellular Resolution

Front Immunol. 2021 Jun 24:12:692222. doi: 10.3389/fimmu.2021.692222. eCollection 2021.

Authors

Tuula Peñate Medina¹, Jan Philip Kolb², Gereon Hüttmann^{2

3}, Robert Huber², Oula Peñate Medina^{1

4}, Linh Ha⁵, Patricia Ulloa⁶, Naomi Larsen⁶, Arianna Ferrari¹, Magdalena Rafecas⁷, Mark Ellrichmann⁸, Mariya S Pravdivtseva^{1

6}, Mariia Anikeeva¹, Jana Humbert^{1

6}, Marcus Both⁶, Jennifer E Hundt⁹, Jan-Bernd Hövener¹

Affiliations

¹ Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center, Schleswig-Holstein Kiel University, Kiel, Germany.
² Institute of Biomedical Optics, University of Lübeck, Lübeck, Germany.
³ Airway Research Center North (ARCN), Member of the German Center of Lung Research (DZL), Gießen, Germany.
⁴ Institute for Experimental Cancer Research (IET), University of Kiel, Kiel, Germany.
⁵ Department of Dermatology, Allergology and Venereology, University Hospital Schleswig-Holstein Lübeck (UKSH), Lübeck, Germany.
⁶ Department of Radiology and Neuroradiology, University Medical Centers Schleswig-Holstein, Campus Kiel, Kiel, Germany.
⁷ Institute of Medical Engineering (IMT), University of Lübeck, Lübeck, Germany.
⁸ Interdisciplinary Endoscopy, Medical Department1, University Hospital Schleswig-Holstein, Kiel, Germany.
⁹ Lübeck Institute for Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.

Abstract

Imaging techniques have evolved impressively lately, allowing whole new concepts like multimodal imaging, personal medicine, theranostic therapies, and molecular imaging to increase general awareness of possiblities of imaging to medicine field. Here, we have collected the selected (3D) imaging modalities and evaluated the recent findings on preclinical and clinical inflammation imaging. The focus has been on the feasibility of imaging to aid in inflammation precision medicine, and the key challenges and opportunities of the imaging modalities are presented. Some examples of the current usage in clinics/close to clinics have been brought out as an example. This review evaluates the future prospects of the imaging technologies for clinical applications in precision medicine from the pre-clinical development point of view.

Keywords: MRI; Optical coherence tomography (OCT); PET; SPECT; Two-Photon microscopy (TPM); hyperpolarization; optical imaging; precision medicine.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Diagnostic Imaging
Humans
Inflammation / diagnostic imaging*