HIF-1: structure, biology and natural modulators

Chao Yang; Zhang-Feng Zhong; Sheng-Peng Wang; Chi-Teng Vong; Bin Yu; Yi-Tao Wang

doi:10.1016/S1875-5364(21)60051-1

HIF-1: structure, biology and natural modulators

Chin J Nat Med. 2021 Jul;19(7):521-527. doi: 10.1016/S1875-5364(21)60051-1.

Authors

Chao Yang¹, Zhang-Feng Zhong², Sheng-Peng Wang², Chi-Teng Vong², Bin Yu³, Yi-Tao Wang⁴

Affiliations

¹ National Engineering Research Center for Marine Aquaculture, Institute of Innovation and Application, Zhejiang Ocean University, Zhoushan 316022, China; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
² State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.
³ School of Pharmaceutical Sciences and Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou 450001, China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: zzuyubin@hotmail.com.
⁴ State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China. Electronic address: ytwang@um.edu.mo.

PMID: 34247775
DOI: 10.1016/S1875-5364(21)60051-1

Abstract

Hypoxia-inducible factor 1 (HIF-1), as a main transcriptional regulator of metabolic adaptation to changes in the oxygen environment, participates in many physiological and pathological processes in the body, and is closely related to the pathogenesis of many diseases. This review outlines the mechanisms of HIF-1 activation, its signaling pathways, natural inhibitors, and its roles in diseases. This article can provide new insights in the diagnosis and treatment of human diseases, and recent progress on the development of HIF-1 inhibitors.

Keywords: Human disease; Hypoxia; Inhibitor; Natural product.

Publication types

Review

MeSH terms

Disease
Humans
Hypoxia-Inducible Factor 1* / physiology
Oxygen
Signal Transduction*

Substances

Hypoxia-Inducible Factor 1
Oxygen