Biochemical properties of fission yeast homologous recombination enzymes

Curr Opin Genet Dev. 2021 Dec:71:19-26. doi: 10.1016/j.gde.2021.06.006. Epub 2021 Jul 7.

Abstract

Homologous recombination (HR) is a universal phenomenon conserved from viruses to humans. The mechanisms of HR are essentially the same in humans and simple unicellular eukaryotes like yeast. Two highly diverged yeast species, Saccharomyces cerevisiae and Schizosaccharomyces pombe, have proven exceptionally useful in understanding the fundamental mechanisms of eukaryotic HR by serving as a source for unique biological insights and also complementing each other. Here, we will review the features of S. pombe HR mechanisms in comparison to S. cerevisiae and other model organisms. Particular emphasis will be put on the biochemical characterization of HR mechanisms uncovered using S. pombe proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Eukaryotic Cells
  • Homologous Recombination / genetics
  • Humans
  • Saccharomyces cerevisiae
  • Schizosaccharomyces pombe Proteins* / genetics
  • Schizosaccharomyces* / genetics

Substances

  • Schizosaccharomyces pombe Proteins