Linking cortical circuit models to human cognition with laminar fMRI

Jiajia Yang; Laurentius Huber; Yinghua Yu; Peter A Bandettini

doi:10.1016/j.neubiorev.2021.07.005

Linking cortical circuit models to human cognition with laminar fMRI

Neurosci Biobehav Rev. 2021 Sep:128:467-478. doi: 10.1016/j.neubiorev.2021.07.005. Epub 2021 Jul 8.

Authors

Jiajia Yang¹, Laurentius Huber², Yinghua Yu³, Peter A Bandettini⁴

Affiliations

¹ Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan; Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, USA. Electronic address: yang@okayama-u.ac.jp.
² MR-Methods Group, Faculty of Psychology and Neuroscience, University of Maastricht, Maastricht, the Netherlands.
³ Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan; Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, USA.
⁴ Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD, USA; Functional MRI Core Facility, National Institute of Mental Health, Bethesda, MD, USA.

PMID: 34245758
DOI: 10.1016/j.neubiorev.2021.07.005

Abstract

Laboratory animal research has provided significant knowledge into the function of cortical circuits at the laminar level, which has yet to be fully leveraged towards insights about human brain function on a similar spatiotemporal scale. The use of functional magnetic resonance imaging (fMRI) in conjunction with neural models provides new opportunities to gain important insights from current knowledge. During the last five years, human studies have demonstrated the value of high-resolution fMRI to study laminar-specific activity in the human brain. This is mostly performed at ultra-high-field strengths (≥ 7 T) and is known as laminar fMRI. Advancements in laminar fMRI are beginning to open new possibilities for studying questions in basic cognitive neuroscience. In this paper, we first review recent methodological advances in laminar fMRI and describe recent human laminar fMRI studies. Then, we discuss how the use of laminar fMRI can help bridge the gap between cortical circuit models and human cognition.

Keywords: Cognition; Cortical circuit models; Cortical layers; Human brain function; Laminar fMRI.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain / diagnostic imaging
Brain Mapping
Cognition
Cognitive Neuroscience*
Humans
Magnetic Resonance Imaging*