The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota

Giuseppe Annunziata; Antoni Sureda; Ilkay Erdogan Orhan; Maurizio Battino; Angela Arnone; Manuel Jiménez-García; Xavier Capó; Joan Cabot; Nima Sanadgol; Francesca Giampieri; Gian Carlo Tenore; Hamid Reza Khayat Kashani; Ana Sanches Silva; Solomon Habtemariam; Seyed Fazel Nabavi; Seyed Mohammad Nabavi

doi:10.1016/j.neubiorev.2021.07.004

The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota

Neurosci Biobehav Rev. 2021 Sep:128:437-453. doi: 10.1016/j.neubiorev.2021.07.004. Epub 2021 Jul 7.

Authors

Giuseppe Annunziata¹, Antoni Sureda², Ilkay Erdogan Orhan³, Maurizio Battino⁴, Angela Arnone⁵, Manuel Jiménez-García⁶, Xavier Capó⁷, Joan Cabot⁸, Nima Sanadgol⁹, Francesca Giampieri¹⁰, Gian Carlo Tenore¹¹, Hamid Reza Khayat Kashani¹², Ana Sanches Silva¹³, Solomon Habtemariam¹⁴, Seyed Fazel Nabavi¹⁵, Seyed Mohammad Nabavi¹⁶

Affiliations

¹ NutraPharmaLabs, Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131, Naples, Italy. Electronic address: giuseppe.annunziata@unina.it.
² Research Group in Community Nutrition and Oxidative Stress and Health Research Institute of the Balearic Islands (IdISBa), University of Balearic Islands-IUNICS, E-07122, Palma de Mallorca, Spain; CIBEROBN (Physiopathology of Obesity and Nutrition), Istituto de Salud Carlos III, 28029 Madrid, Spain. Electronic address: antoni.sureda@uib.es.
³ Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330, Ankara, Turkey. Electronic address: iorhan@gazi.edu.tr.
⁴ Nutrition and Food Science Group, Department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo - Vigo Campus, Vigo, Spain; Dept of Clinical Sciences, Università Politecnica delle Marche, Ancona, Italy; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China. Electronic address: m.a.battino@staff.univpm.it.
⁵ Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology, Federico II University Medical School of Naples, Via Sergio Pansini 5, 80131, Naples, Italy. Electronic address: angela.arnone15@gmail.com.
⁶ Laboratory of Neurophysiology, Biology Department, University of Balearic Islands (UIB), Ctra. Valldemossa Km 7.5, E-07122, Palma de Mallorca, Spain. Electronic address: manuel.jimenez@uib.es.
⁷ Research Group in Community Nutrition and Oxidative Stress and Health Research Institute of the Balearic Islands (IdISBa), University of Balearic Islands-IUNICS, E-07122, Palma de Mallorca, Spain. Electronic address: xavier.capo@uib.es.
⁸ Biology Department, University of Balearic Islands (UIB), Ctra. Valldemossa Km 7.5, E-07122 Palma de Mallorca, Spain. Electronic address: joancabotbauza@gmail.com.
⁹ Department of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran; Department of Biomolecular Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil. Electronic address: sanadgol.n@gmail.com.
¹⁰ Department of Odontostomatologic and Specialized Clinical Sciences, Faculty of Medicine, Polytechnic University of Marche, Ancona, Italy; Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: f.giampieri@univpm.it.
¹¹ NutraPharmaLabs, Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131, Naples, Italy. Electronic address: giancarlo.tenore@unina.it.
¹² Imam Hossein Hospital, Madani street, Theran, Iran. Electronic address: hrkhka@gmail.com.
¹³ National Institute of Agrarian and Veterinary Research (INIAV), Rua dos Lágidos, Lugar da Madalena, Vairão, Vila do Conde, Oporto, 4485-655, Portugal; Center for Study in Animal Science (CECA), ICETA, University of Oporto, Oporto, Portugal. Electronic address: anateress@gmail.com.
¹⁴ Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of Greenwich, Central Avenue, Charham-Maritime, Kent, ME4 4TB, UK. Electronic address: s.habtemariam@herbalanalysis.co.uk.
¹⁵ Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: nabavisf@gmail.com.
¹⁶ Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: nabavi208@gmail.com.

PMID: 34245757
DOI: 10.1016/j.neubiorev.2021.07.004

Abstract

Neurodegenerative disorders, particularly in the elderly population, represent one of the most pressing social and health-care problems in the world. Besides the well-established role of both oxidative stress and inflammation, alterations of the immune response have been found to be closely linked to the development of neurodegenerative diseases. Interestingly, various scientific evidence reported that an altered gut microbiota composition may contribute to the development of neuroinflammatory disorders. This leads to the proposal of the concept of the gut-brain-immune axis. In this scenario, polyphenols play a pivotal role due to their ability to exert neuroprotective, immunomodulatory and microbiota-remodeling activities. In the present review, we summarized the available literature to provide a scientific evidence regarding this neuroprotective and immunomodulatory effects and the interaction with gut microbiota of polyphenols and, the main signaling pathways involved that can explain their potential therapeutic application in neurodegenerative diseases.

Keywords: aging-related cognitive decline; innate immunity; neurodegeneration; nutraceutical; polyphenols.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aged
Gastrointestinal Microbiome*
Humans
Immunity, Innate
Microbiota*
Neuroprotective Agents* / pharmacology
Neuroprotective Agents* / therapeutic use
Polyphenols / pharmacology

Substances

Neuroprotective Agents
Polyphenols