Autoimmunity to annexin A2 predicts mortality among hospitalised COVID-19 patients

Marisol Zuniga; Claudia Gomes; Steven E Carsons; Michael T Bender; Paolo Cotzia; Qing Robert Miao; David C Lee; Ana Rodriguez

doi:10.1183/13993003.00918-2021

Autoimmunity to annexin A2 predicts mortality among hospitalised COVID-19 patients

Eur Respir J. 2021 Oct 21;58(4):2100918. doi: 10.1183/13993003.00918-2021. Print 2021 Oct.

Authors

Marisol Zuniga^{1

2}, Claudia Gomes^{1

2}, Steven E Carsons³, Michael T Bender⁴, Paolo Cotzia⁵, Qing Robert Miao⁶, David C Lee^{7

8

9}, Ana Rodriguez^{1

9}

Affiliations

¹ Dept of Microbiology, NYU Grossman School of Medicine, New York, NY, USA.
² M. Zuniga and C. Gomes contributed equally to this work.
³ Division of Rheumatology, Dept of Medicine, NYU Long Island School of Medicine, New York, NY, USA.
⁴ Division of Pulmonology and Critical Care Medicine, Dept of Medicine, NYU Long Island School of Medicine, New York, NY, USA.
⁵ Dept of Pathology, NYU Grossman School of Medicine, New York, NY, USA.
⁶ Dept of Foundations of Medicine, NYU Long Island School of Medicine, New York, NY, USA.
⁷ Dept of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA david.lee@nyumc.org.
⁸ Dept of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
⁹ D.C. Lee and A. Rodriguez contributed equally to this article as lead authors and supervised the work.

Abstract

Levels of anti-annexin A2 antibodies at admission strongly predicted mortality among hospitalised COVID-19 patients. Given its critical protective function in the lung, annexin A2 antagonism may play an important role in the pathophysiology of COVID-19. https://bit.ly/2UMPr9w

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Annexin A2*
Autoimmunity
COVID-19*
Humans
SARS-CoV-2

Substances

ANXA2 protein, human
Annexin A2