Enhancing the tumor cell selectivity of a rhodamine-decorated iridium(III) complex by conjugating with indomethacin for COX-2 targeted photodynamic therapy

Chuangjun Liu; Jingjing Xiang; Chunbai Xiang; Hongfeng Li

doi:10.1016/j.bioorg.2021.105142

Enhancing the tumor cell selectivity of a rhodamine-decorated iridium(III) complex by conjugating with indomethacin for COX-2 targeted photodynamic therapy

Bioorg Chem. 2021 Sep:114:105142. doi: 10.1016/j.bioorg.2021.105142. Epub 2021 Jul 1.

Authors

Chuangjun Liu¹, Jingjing Xiang², Chunbai Xiang², Hongfeng Li²

Affiliations

¹ College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. Electronic address: Liuchuangjun@huanghuai.edu.cn.
² Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

PMID: 34243072
DOI: 10.1016/j.bioorg.2021.105142

Abstract

A rhodamine-iridium (III) complex bearing indomethacin moiety, named IM-rho-Ir, was synthesized and evaluated for COX-2 targetable photodynamic therapy. By integrating COX-2 directing group, IM-rho-Ir exhibited enhanced cellular uptake in cancer cells than in normal cells compared to rhodamine-iridium (III) complex without indomethacin moiety.

Keywords: COX-2; Photodynamic therapy; Photosensitizer; Rhodamine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Cell Proliferation / drug effects
Cell Survival / drug effects
Coordination Complexes / chemical synthesis
Coordination Complexes / chemistry
Coordination Complexes / pharmacology*
Cyclooxygenase 2 / metabolism
Cyclooxygenase 2 Inhibitors / chemical synthesis
Cyclooxygenase 2 Inhibitors / chemistry
Cyclooxygenase 2 Inhibitors / pharmacology*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Female
Humans
Indomethacin / chemistry
Indomethacin / pharmacology
Iridium / chemistry
Iridium / pharmacology
MCF-7 Cells
Mammary Neoplasms, Experimental / drug therapy
Mammary Neoplasms, Experimental / metabolism
Mammary Neoplasms, Experimental / pathology
Mice
Mice, Nude
Molecular Structure
Photochemotherapy*
Photosensitizing Agents / chemical synthesis
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology*
Rhodamines / chemistry
Rhodamines / pharmacology
Structure-Activity Relationship

Substances

Antineoplastic Agents
Coordination Complexes
Cyclooxygenase 2 Inhibitors
Photosensitizing Agents
Rhodamines
Iridium
Cyclooxygenase 2
Indomethacin