Sarcopenia measurement in research and clinical practice

Eur J Intern Med. 2021 Aug:90:1-9. doi: 10.1016/j.ejim.2021.06.003. Epub 2021 Jul 6.

Abstract

Sarcopenia is a disease related to accelerated loss of skeletal muscle and subsequent decline in functional capacity. It affects approximately 13% of the world's population aged over 60 years. Sarcopenia is primarily managed and prevented through a combination of exercise prescription combined with appropriate nutritional strategies. This review outlines diagnostic and case finding/screening tools for age-related (primary) sarcopenia used in research and clinical practice. Diagnostic tools critically reviewed include those of the: European Workgroup for Sarcopenia (EWGSOP) versions 1 and 2; Asian Working Group for Sarcopenia (AWGS) versions 1 and 2; Foundation for the National Institutes of Health (FNIH); and the Sarcopenia Definition and Outcomes Consortium (SDOC). Criteria used by diagnostic tools (muscle mass, muscle strength and physical functioning/performance) are also detailed. Case-finding tools include the SARC-F questionnaire, Ishii's formula and Goodman's screening grid. Additionally, this review discusses the strengths and weaknesses of each diagnostic and case-finding tool, and examines their ability to reliably predict adverse clinical outcomes and patient responses to potential therapies.

Keywords: 80 and over; Aged; Geriatric assessment/methods; Sarcopenia.

Publication types

  • Review

MeSH terms

  • Aged
  • Cross-Sectional Studies
  • Geriatric Assessment
  • Hand Strength
  • Humans
  • Muscle Strength
  • Muscle, Skeletal
  • Sarcopenia* / diagnosis
  • Surveys and Questionnaires