Association Between miR-146a rs2910164 Polymorphism and Breast Cancer Susceptibility: An Updated Meta-Analysis of 9545 Cases and 10030 Controls

Abdolkarim Moazeni-Roodi; Sajjad Aftabi; Sahel Sarabandi; Shima Karami; Mohammad Hashemi; Saeid Ghavami; Mohsen Taheri

doi:10.2174/2211536610666210707113229

Association Between miR-146a rs2910164 Polymorphism and Breast Cancer Susceptibility: An Updated Meta-Analysis of 9545 Cases and 10030 Controls

Microrna. 2021;10(3):191-199. doi: 10.2174/2211536610666210707113229.

Authors

Abdolkarim Moazeni-Roodi¹, Sajjad Aftabi², Sahel Sarabandi³, Shima Karami³, Mohammad Hashemi⁴, Saeid Ghavami⁵, Mohsen Taheri⁶

Affiliations

¹ Tropical and Communicable Diseases Research Center, Iranshahr University of Medical Sciences, Iranshahr,Iran | Department of Clinical Biochemistry, Iranshahr University of Medical Sciences, Iranshahr, Iran.
² Medical Physics Department, Cancer Care Manitoba, Winnipeg,Canada | Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
³ Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan,Iran.
⁴ Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan,Iran | Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
⁵ Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg,Canada | Research Institute in Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, Canada.
⁶ Genetics of Non-communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan,Iran | Department of Genetic, School of Medicine, Zahedan University of Medical Sciences, Zahed an, Iran.

PMID: 34238177
DOI: 10.2174/2211536610666210707113229

Abstract

Background: Several studies have reported a possible association of miR-146a rs2910164 polymorphism with Breast Cancer (BC) development. However, the correlation between this polymorphism and susceptibility to BC is under debate. The current meta-analysis was designed and performed to more conclusively evaluate the miR-146a rs2910164 polymorphism and its potential link to BC.

Methods: Our team has selected eligible studies (published up to October 2, 2020) from several electronic databases, including Web of Science, PubMed, Scopus and Google Scholar. A total number of 9,545 BC cases and 10,030 controls extracted from 26 eligible articles were included in this study. We utilized pooled Odds Ratios (ORs) as well as 95% confidence intervals (95% CIs) under five genetic models for quantitative estimation of any possible association between miR-146a rs2910164 polymorphism and BC.

Results: Based on this meta-analysis, our findings suggest that there is no significant association between miR-146a rs2910164 polymorphism and BC risk. However, stratified analysis revealed that the rs2910164 polymorphism significantly increased the risk of BC in hospital-based studies using the homozygous genetic model (OR=1.37, 95%CI=1.01-1.86, p=0.043, CC vs. GG). Neither Asian nor Caucasian populations showed any significant association between rs2910164 polymorphism and BC susceptibility.

Conclusion: In summary, our findings suggest that BC development is not associated with miR-146a rs2910164 polymorphism. However, larger ingenious future investigations might be needed for a more precise estimation of any association between miR-146a rs2910164 polymorphism and BC.

Keywords: Breast cancer; meta-analysis; mir-146a; odd ratios; polymorphism; single nucleotide polymorphisms (SNPs.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Asian People
Breast Neoplasms* / genetics
Case-Control Studies
Female
Genetic Predisposition to Disease
Humans
MicroRNAs / genetics*
Polymorphism, Single Nucleotide

Substances

MIRN146 microRNA, human
MicroRNAs