Abstract
Glycosylation plays important roles in SARS-CoV-2 infection. We describe here a facile chemoenzymatic synthesis of core-fucosylated N-glycopeptides derived from the SARS-CoV-2 Spike protein and their binding with glycan-dependent neutralizing antibody S309 and human lectin CLEC4G. The synthetic glycopeptides provide tools for further functional characterization of viral glycosylation.
MeSH terms
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Antibodies, Neutralizing / immunology
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Chemistry Techniques, Synthetic
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Glycopeptides / chemical synthesis*
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Glycopeptides / chemistry
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Glycopeptides / immunology
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Glycopeptides / metabolism*
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Glycosylation
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Polysaccharides / metabolism
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Spike Glycoprotein, Coronavirus / chemistry*
Substances
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Antibodies, Neutralizing
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Glycopeptides
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Polysaccharides
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Spike Glycoprotein, Coronavirus
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spike protein, SARS-CoV-2