Anionic diketopiperazine induces osteogenic differentiation and supports osteogenesis in a 3D cryogel microenvironment

Chem Commun (Camb). 2021 Jul 27;57(60):7422-7425. doi: 10.1039/d1cc01985f.

Abstract

Bioactive molecules that enhance or induce osteogenic potential of bone precursor cells have shown vital roles in bone tissue engineering. Herein, we report the design and synthesis of a novel diketopiperazine (DT) that induces osteoblastic differentiation of pre-osteoblasts and bone-marrow-derived stem cells in vitro and enhances the osteogenic potential of cryogel matrix. Such functional diketopiperazines can serve as potential scaffolds for bone healing and regeneration.

MeSH terms

  • Animals
  • Cell Differentiation / drug effects*
  • Cell Proliferation / drug effects
  • Cryogels / chemistry*
  • Diketopiperazines / chemical synthesis
  • Diketopiperazines / pharmacology*
  • Diketopiperazines / toxicity
  • Mesenchymal Stem Cells / drug effects
  • Mice
  • Osteoblasts / drug effects
  • Osteogenesis / drug effects*
  • Peptides, Cyclic / chemical synthesis
  • Peptides, Cyclic / pharmacology*
  • Peptides, Cyclic / toxicity
  • Taurine / analogs & derivatives
  • Taurine / pharmacology
  • Taurine / toxicity
  • Tissue Engineering / methods
  • Tissue Scaffolds / chemistry*

Substances

  • Cryogels
  • Diketopiperazines
  • Peptides, Cyclic
  • Taurine