Abstract
Bioactive molecules that enhance or induce osteogenic potential of bone precursor cells have shown vital roles in bone tissue engineering. Herein, we report the design and synthesis of a novel diketopiperazine (DT) that induces osteoblastic differentiation of pre-osteoblasts and bone-marrow-derived stem cells in vitro and enhances the osteogenic potential of cryogel matrix. Such functional diketopiperazines can serve as potential scaffolds for bone healing and regeneration.
MeSH terms
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Animals
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Cell Differentiation / drug effects*
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Cell Proliferation / drug effects
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Cryogels / chemistry*
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Diketopiperazines / chemical synthesis
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Diketopiperazines / pharmacology*
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Diketopiperazines / toxicity
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Mesenchymal Stem Cells / drug effects
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Mice
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Osteoblasts / drug effects
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Osteogenesis / drug effects*
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Peptides, Cyclic / chemical synthesis
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Peptides, Cyclic / pharmacology*
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Peptides, Cyclic / toxicity
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Taurine / analogs & derivatives
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Taurine / pharmacology
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Taurine / toxicity
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Tissue Engineering / methods
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Tissue Scaffolds / chemistry*
Substances
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Cryogels
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Diketopiperazines
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Peptides, Cyclic
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Taurine