The Association of MMP9 Promoter Rs3918242 Genotype With Gastric Cancer

Chun-Kai Fu; Wen-Shin Chang; Chia-Wen Tsai; Yun-Chi Wang; Mei-Due Yang; Hua-Shai Hsu; Che-Yi Chao; Chien-Chih Yu; Jaw-Chyun Chen; Jen-Sheng Pei; DA-Tian Bau

doi:10.21873/anticanres.15118

The Association of MMP9 Promoter Rs3918242 Genotype With Gastric Cancer

Anticancer Res. 2021 Jul;41(7):3309-3315. doi: 10.21873/anticanres.15118.

Authors

Chun-Kai Fu^{1

2

3

4}, Wen-Shin Chang^{1

3}, Chia-Wen Tsai^{1

3}, Yun-Chi Wang^{1

3}, Mei-Due Yang³, Hua-Shai Hsu⁵, Che-Yi Chao⁶, Chien-Chih Yu³, Jaw-Chyun Chen⁷, Jen-Sheng Pei⁸, DA-Tian Bau^{9

3

10}

Affiliations

¹ Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
² Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
³ Terry Fox Cancer Research Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
⁴ National Defense Medical Center, Taipei, Taiwan, R.O.C.
⁵ Department of Medical Imaging, China Medical University Hospital, Taichung, Taiwan, R.O.C.
⁶ Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan, R.O.C.
⁷ Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua, Taiwan, R.O.C.
⁸ Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
⁹ Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.; artbau2@gmail.com.
¹⁰ Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan, R.O.C.

PMID: 34230126
DOI: 10.21873/anticanres.15118

Abstract

Background/aim: Matrix metalloproteinase 9 (MMP9) is highly expressed in gastric cancer but the role of MMP9 is unclear. This study aimed at revealing the association of MMP9 promoter rs3918242 genotypes with gastric cancer risk.

Materials and methods: MMP9 rs3918242 genotypes of 121 patients with gastric cancer and 363 healthy individuals were examined by polymerase chain reaction-restriction fragment length polymorphism methodology using serum samples.

Results: MMP9 rs3918242 TT genotype carriers had an elevated gastric cancer risk compared to wild-type CC carriers (odds ratio=3.92, 95% confidence interval=1.28-11.99; p=0.0103). Patients with CT/TT genotypes were at higher risk of metastasis (p=0.0178) than those with CC. No correlation was found between MMP9 rs3918242 genotype and gastric cancer risk with smoking or alcohol behavior, nor Helicobacter pylori infection. No correlation was observed for MMP9 rs3918242 genotypic distributions with age, gender, or body mass index.

Conclusion: Carrying a T allele for MMP9 rs3918242 may be predictive for higher gastric cancer risk, and as a predictor for higher risk of metastasis.

Keywords: Gastric cancer; MMP9; Taiwan; genotype; polymorphism.

MeSH terms

Case-Control Studies
Female
Genetic Predisposition to Disease / genetics*
Genotype
Helicobacter Infections / genetics
Helicobacter pylori / pathogenicity
Humans
Male
Matrix Metalloproteinase 9 / genetics*
Middle Aged
Polymorphism, Restriction Fragment Length / genetics
Promoter Regions, Genetic / genetics*
Risk Factors
Stomach Neoplasms / genetics*

Substances

MMP9 protein, human
Matrix Metalloproteinase 9