Biomembranes in bioelectronic sensing

Trends Biotechnol. 2022 Jan;40(1):107-123. doi: 10.1016/j.tibtech.2021.06.001. Epub 2021 Jul 3.

Abstract

Cell membranes are integral to the functioning of the cell and are therefore key to drive fundamental understanding of biological processes for downstream applications. Here, we review the current state-of-the-art with respect to biomembrane systems and electronic substrates, with a view of how the field has evolved towards creating biomimetic conditions and improving detection sensitivity. Of particular interest are conducting polymers, a class of electroactive polymers, which have the potential to create the next step-change for bioelectronics devices. Lastly, we discuss the impact these types of devices could have for biomedical applications.

Keywords: bioelectronics; biomembrane sensors; label-free; membrane biophysics; supported lipid bilayers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomimetics
  • Biosensing Techniques* / methods
  • Cell Membrane
  • Electronics*
  • Polymers

Substances

  • Polymers