A Systematic Analysis of Metal and Metalloid Concentrations in Eight Zebrafish Recirculating Water Systems

Zebrafish. 2021 Aug;18(4):252-264. doi: 10.1089/zeb.2020.1970. Epub 2021 Jul 5.

Abstract

Metals and metalloids are integral to biological processes and play key roles in physiology and metabolism. Nonetheless, overexposure to some metals or lack of others can lead to serious health consequences. In this study, eight zebrafish facilities collaborated to generate a multielement analysis of their centralized recirculating water systems. We report a first set of average concentrations for 46 elements detected in zebrafish facilities. Our results help to establish an initial baseline for trouble-shooting purposes, and in general for safe ranges of metal concentrations in recirculating water systems, supporting reproducible scientific research outcomes with zebrafish.

Keywords: animal welfare; aquatic models; environment; fish nutrition; metal requirement; metal toxicity; reproducibility; standards; water quality; zebrafish husbandry.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Metalloids* / analysis
  • Metalloids* / metabolism
  • Water
  • Water Pollutants, Chemical* / analysis
  • Zebrafish / metabolism

Substances

  • Metalloids
  • Water Pollutants, Chemical
  • Water