MRI maps, segregation, and white matter connectivity of the human hypothalamus in health

Handb Clin Neurol. 2021:179:87-94. doi: 10.1016/B978-0-12-819975-6.00003-0.

Abstract

The human hypothalamus is composed of several gray matter territories, forming 10 different structures mainly referred to as nuclei: the preoptic, suprachiasmatic, supraoptic, infundibular, paraventricular, dorsomedial, ventromedial, posterior (dorsal; dorsal hypothalamic area), and tuberomamillary nuclei, and the lateral hypothalamic area. The macroconnectivity, described since the middle of the 19th century, is currently probed using MRI methods, notably those relying on diffusion techniques. The structural connections can be grouped as follows: connections with the olfactory system; stria terminalis connections; stria medullaris connections; ansa lenticularis connections; subthalamus connections; optic tract connections; intrahypothalamic connections; hypothalamo-hypophysis connections; hypothalamic commissures; cortex connections.

Keywords: Connectivity; DTI; Diencephalon; Hypothalamus; MRI; limbic system.

Publication types

  • Review

MeSH terms

  • Cerebral Cortex
  • Humans
  • Hypothalamus
  • Magnetic Resonance Imaging
  • Thalamus
  • White Matter* / diagnostic imaging