Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Danielle E Large; Rudolf G Abdelmessih; Elizabeth A Fink; Debra T Auguste

doi:10.1016/j.addr.2021.113851

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Adv Drug Deliv Rev. 2021 Sep:176:113851. doi: 10.1016/j.addr.2021.113851. Epub 2021 Jul 2.

Authors

Danielle E Large¹, Rudolf G Abdelmessih¹, Elizabeth A Fink¹, Debra T Auguste²

Affiliations

¹ Department of Chemical Engineering, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.
² Department of Chemical Engineering, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA. Electronic address: d.auguste@northeastern.edu.

PMID: 34224787
DOI: 10.1016/j.addr.2021.113851

Abstract

Liposomal drug delivery represents a highly adaptable therapeutic platform for treating a wide range of diseases. Natural and synthetic lipids, as well as surfactants, are commonly utilized in the synthesis of liposomal drug delivery vehicles. The molecular diversity in the composition of liposomes enables drug delivery with unique physiological functions, such as pH response, prolonged blood circulation, and reduced systemic toxicity. Herein, we discuss the impact of composition on liposome synthesis, function, and clinical utility.

Keywords: Liposomal drug delivery; Liposome functionality; Liposome synthesis.

Publication types

Review

MeSH terms

Animals
Drug Delivery Systems*
Drug Design*
Humans
Hydrogen-Ion Concentration
Lipids / chemistry*
Liposomes
Pharmaceutical Preparations / administration & dosage
Pharmaceutical Preparations / chemistry
Surface-Active Agents / chemistry

Substances

Lipids
Liposomes
Pharmaceutical Preparations
Surface-Active Agents