Evaluation of a strategy for difficult embryo transfers from a prospective series of 2,046 transfers

Lionel Larue; Laure Bernard; Julie Moulin; Anne Massari; Nino-Guy Cassuto; Dominique Bouret; Gwenola Keromnes

doi:10.1016/j.xfre.2020.11.004

Evaluation of a strategy for difficult embryo transfers from a prospective series of 2,046 transfers

F S Rep. 2020 Dec 9;2(1):43-49. doi: 10.1016/j.xfre.2020.11.004. eCollection 2021 Mar.

Authors

Lionel Larue¹, Laure Bernard¹, Julie Moulin¹, Anne Massari¹, Nino-Guy Cassuto², Dominique Bouret², Gwenola Keromnes¹

Affiliations

¹ Centre de Fertilité - Groupe Hospitalier Diaconesses Croix Saint Simon, Paris, France.
² Laboratoire Drouot, Paris, France.

Abstract

Objective: To evaluate an embryo transfer strategy for difficult transfers (DiTs).

Design: Prospective, nonrandomized, observational, cohort study.

Setting: A hospital fertility center in France.

Patients: Data were collected on all embryo transfers conducted using the strategy between February 2014 and February 2020.

Interventions: Anatomical characteristics that could cause DiT were identified by transvaginal ultrasound and the catheter was adapted accordingly. Transfer was guided by transvaginal ultrasound. After passage through the cervix, a rest period was introduced to allow any contractions to stop before embryo deposition in the uterus.

Main outcome measures: The primary criterion was the percentage of pregnancies per transfer (P/T) after an easy transfer (EaT) or a DiT. The secondary criteria included the anatomical causes of DiT and the patients' levels of discomfort.

Results: Of 2,046 transfers, 257 (12%) were DiTs: minor difficulties (n = 152; 7.4%), major difficulties (n = 96; 4.7%), very significant difficulties (n = 7; 0.3%), or impossible (n = 2; 0.1%). The most common causes of DiTs were endocervical crypts (54%), tortuous cervical canal (36%), and marked uterine anteversions (30%). Several causes were often responsible for DiTs. There was no statistically significant difference in the P/T between the EaTs (n = 1,789, 41%) and all degrees of DiT (n = 257, 37%). In addition, there was no statistically significant difference between the level of patient-reported discomfort in the EaT and DiT groups.

Conclusions: This study demonstrated that an adapted embryo transfer strategy, monitored by transvaginal ultrasound, led to similar pregnancy rates regardless of whether the transfer was easy or difficult.

Keywords: Embryo transfer; difficult transfer; in vitro fertilization; personalized healthcare; transvaginal ultrasound.