With increasing pathogenic bacterial infection that is occurring worldwide, antibacterial therapy has become an important research field. There is great antimicrobial potential in the nanomaterial-based metal-organic framework (MOF) platform because it is highly biocompatible, biodegradable, and nontoxic, and it is now widely used in the anticancer agent industry and in the production of medical products. This review summarizes the possible mechanisms of representative MOF-based nanomaterials, and recounts recent progress in the design and development of MOF-based antibacterial materials for the remedy of postoperative infection. The existing shortcomings and future perspectives of the rapidly growing field of antimicrobial therapy addressing patient quality of life issues are also briefly discussed. Because of their wide applicability, further studies on the use of different MOF antimicrobial therapies will be of great interest.
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