Idiopathic pure sudomotor failure: A review and two cases

Albert T Young; Raagini S Yedidi; Jodie Raffi; Timothy H McCalmont; Jeffrey North; Alyson Brinker; Timothy G Berger; Jenny E Murase

doi:10.1016/j.ijwd.2020.12.011

Idiopathic pure sudomotor failure: A review and two cases

Int J Womens Dermatol. 2020 Dec 24;7(3):276-279. doi: 10.1016/j.ijwd.2020.12.011. eCollection 2021 Jun.

Authors

Albert T Young¹, Raagini S Yedidi¹, Jodie Raffi^{1

2}, Timothy H McCalmont^{1

3}, Jeffrey North^{1

3}, Alyson Brinker⁴, Timothy G Berger¹, Jenny E Murase^{1

5}

Affiliations

¹ Department of Dermatology, University of California, San Francisco, San Francisco, CA, United States.
² School of Medicine, University of California, Irvine, Irvine, CA, United States.
³ Department of Pathology, University of California, San Francisco, San Francisco, CA, United States.
⁴ Naval Medical Center San Diego, San Diego, CA, United States.
⁵ Department of Dermatology, Palo Alto Foundation Medical Group, Mountain View, CA, United States.

Abstract

Idiopathic pure sudomotor failure (IPSF) is a rare disease characterized by acquired impairment in total body sweating despite exposure to heat or exercise. Its etiology is unknown but thought to involve defective cholinergic receptors on eccrine sweat glands. This article reviews the epidemiology, pathophysiology, presentation, and management of IPSF. Additionally, we report two cases of IPSF treated with multimodal therapy, including stacked antihistamine regimens and omalizumab, resulting in symptom improvement. This is the first report of treatment of IPSF with omalizumab, although its benefit is uncertain and requires further study.

Keywords: AIGA; IPSF; Idiopathic pure sudomotor failure.

Publication types

Review