Diverse Roles of TgMIC1/4/6 in the Toxoplasma Infection

Jinjin Zhu; Yang Wang; Yuanyuan Cao; Jilong Shen; Li Yu

doi:10.3389/fmicb.2021.666506

Diverse Roles of TgMIC1/4/6 in the Toxoplasma Infection

Front Microbiol. 2021 Jun 17:12:666506. doi: 10.3389/fmicb.2021.666506. eCollection 2021.

Authors

Jinjin Zhu¹, Yang Wang¹, Yuanyuan Cao¹, Jilong Shen¹, Li Yu¹

Affiliation

¹ The Key Laboratory of Microbiology and Parasitology of Anhui Province, The Key Laboratory of Zoonoses of High Institutions in Anhui, Department of Microbiology and Parasitology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Abstract

Toxoplasma gondii microneme is a specialized secretory organelle that discharges its contents at the apical tip of this apicomplexan parasite in a sequential and regulated manner. Increasing number of studies on microneme proteins (MICs) have shown them as a predominant and important role in host cell attachment, invasion, motility and pathogenesis. In this review, we summarize the research advances in one of the most important MICs complexes, TgMIC1/4/6, which will contribute to improve the understanding of the molecular mechanism of T. gondii infection and provide a theoretical basis for the effective control against T. gondii.

Keywords: MIC1; MIC4; MIC6; Toxoplasma gondii; invasion.

Publication types

Review