Rational design of phenyl thiophene (pyridine) derivatives that overcome P-glycoprotein mediated MDR in MCF-7/ADR cell

Bioorg Chem. 2021 Sep:114:105075. doi: 10.1016/j.bioorg.2021.105075. Epub 2021 Jun 8.

¹ College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Del-ta Region, Zhejiang University of Technology, Hangzhou 310014, China.
² Department of Pharmacy, Quanzhou Medical College, Quanzhou 362100, China.
³ College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Del-ta Region, Zhejiang University of Technology, Hangzhou 310014, China; Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA.
⁴ State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China. Electronic address: ziningcui@scau.edu.cn.
⁵ College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Del-ta Region, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address: cjw983617@zjut.edu.cn.
⁶ College of Pharmaceutical Science & Green Pharmaceutical Collaborative Innovation Center of Yangtze River Del-ta Region, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address: hongw@zjut.edu.cn.

No abstract available

Keywords: MCF-7/ADR; P-glycoprotein; Pyridine; Structure-activity relationship; Thiophene.

Publication types

ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
Antibiotics, Antineoplastic / chemistry
Antibiotics, Antineoplastic / pharmacology
Cell Line, Tumor
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Doxorubicin / chemistry
Doxorubicin / pharmacology
Drug Design*
Drug Resistance, Neoplasm / drug effects*
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Neoplasms / drug therapy*
Neoplasms / metabolism
Neoplasms / pathology
Pyridines / chemical synthesis
Pyridines / chemistry
Pyridines / pharmacology*
Structure-Activity Relationship
Thiophenes / chemical synthesis
Thiophenes / chemistry
Thiophenes / pharmacology*