Putative role of natural products as Protein Kinase C modulator in different disease conditions

Rishi Kant Singh; Sanjay Kumar; Munendra Singh Tomar; Praveen Kumar Verma; Amit Kumar; Sandeep Kumar; Naveen Kumar; Jai Prakash Singh; Arbind Acharya

doi:10.1007/s40199-021-00401-z

Putative role of natural products as Protein Kinase C modulator in different disease conditions

Daru. 2021 Dec;29(2):397-414. doi: 10.1007/s40199-021-00401-z. Epub 2021 Jul 3.

Authors

Rishi Kant Singh¹, Sanjay Kumar², Munendra Singh Tomar³, Praveen Kumar Verma¹, Amit Kumar¹, Sandeep Kumar¹, Naveen Kumar¹, Jai Prakash Singh⁴, Arbind Acharya⁵

Affiliations

¹ Department of Zoology, Institute of Science, BHU, Varanasi, 221005, India.
² School of Life Sciences, JNU, New Delhi, India.
³ Department of Pharmaceutical Science, School of Pharmacy, University of Colorado, Denver, USA.
⁴ Department of Panchkarma, Institute of Medical Science, BHU, Varanasi, India, 221005.
⁵ Department of Zoology, Institute of Science, BHU, Varanasi, 221005, India. acharya@bhu.ac.in.

Abstract

Introduction: Protein kinase C (PKC) is a promising drug target for various therapeutic areas. Natural products derived from plants, animals, microorganisms, and marine organisms have been used by humans as medicine from prehistoric times. Recently, several compounds derived from plants have been found to modulate PKC activities through competitive binding with ATP binding site, and other allosteric regions of PKC. As a result fresh race has been started in academia and pharmaceutical companies to develop an effective naturally derived small-molecule inhibitor to target PKC activities. Herein, in this review, we have discussed several natural products and their derivatives, which are reported to have an impact on PKC signaling cascade.

Methods: All information presented in this review article regarding the regulation of PKC by natural products has been acquired by a systematic search of various electronic databases, including ScienceDirect, Scopus, Google Scholar, Web of science, ResearchGate, and PubMed. The keywords PKC, natural products, curcumin, rottlerin, quercetin, ellagic acid, epigallocatechin-3 gallate, ingenol 3 angelate, resveratrol, protocatechuic acid, tannic acid, PKC modulators from marine organism, bryostatin, staurosporine, midostaurin, sangivamycin, and other relevant key words were explored.

Results: The natural products and their derivatives including curcumin, rottlerin, quercetin, ellagic acid, epigallocatechin-3 gallate, ingenol 3 angelate, resveratrol, bryostatin, staurosporine, and midostaurin play a major role in the management of PKC activity during various disease progression.

Conclusion: Based on the comprehensive literature survey, it could be concluded that various natural products can regulate PKC activity during disease progression. However, extensive research is needed to circumvent the challenge of isoform specific regulation of PKC by natural products.

Keywords: Cancer; Cardiac disease; Drug target; Natural products; Neurodegenerative diseases.

Publication types

Review

MeSH terms

Allosteric Regulation
Animals
Aquatic Organisms / chemistry
Biological Products / chemistry
Biological Products / pharmacology*
Disease Progression
Gene Expression Regulation, Enzymologic / drug effects
Humans
Phytochemicals / chemistry
Phytochemicals / metabolism
Protein Kinase C / antagonists & inhibitors
Protein Kinase C / chemistry
Protein Kinase C / metabolism*
Signal Transduction / drug effects
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology*

Substances

Biological Products
Phytochemicals
Small Molecule Libraries
Protein Kinase C