Alteration of gut microbiota in acute pancreatitis and associated therapeutic strategies

Ying Zhu; Qixiang Mei; Yang Fu; Yue Zeng

doi:10.1016/j.biopha.2021.111850

Alteration of gut microbiota in acute pancreatitis and associated therapeutic strategies

Biomed Pharmacother. 2021 Sep:141:111850. doi: 10.1016/j.biopha.2021.111850. Epub 2021 Jun 30.

Authors

Ying Zhu¹, Qixiang Mei¹, Yang Fu¹, Yue Zeng²

Affiliations

¹ Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai 201600, China; Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 201600, China.
² Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 201600, China. Electronic address: carrie_1004@sjtu.edu.cn.

PMID: 34214727
DOI: 10.1016/j.biopha.2021.111850

Abstract

Gut microbiome is considered as a crucial regulator of human health. Alteration of gut microbiome has been reported in acute pancreatitis (AP) and probably contributes to the severity of disease. Explore the precise role of gut microbiome in the pathogenesis of AP could offer new strategies to improve the clinical outcomes of AP. This review summarizes the role of gut microbiome in AP, lists possible mechanisms associated with it and offers an overview of current treatments based on gut microbiome.

Keywords: Acute pancreatitis; Bacterial translocation; Gut homeostasis; Gut microbiome; Microbiome-based treatment.

Publication types

Review

MeSH terms

Animals
Anti-Bacterial Agents / therapeutic use
Dysbiosis
Gastrointestinal Microbiome*
Humans
Pancreatitis / microbiology*
Pancreatitis / physiopathology
Pancreatitis / therapy
Probiotics / therapeutic use

Substances

Anti-Bacterial Agents