Building and destroying synaptic bridges: How do Hevin/Sparcl1, SPARC, and MDGAs modify trans-synaptic neurexin-neuroligin interactions?

Juan J Ramirez; Dhanesh Sivadasan Bindu; Cagla Eroglu

doi:10.1016/j.str.2021.06.011

Building and destroying synaptic bridges: How do Hevin/Sparcl1, SPARC, and MDGAs modify trans-synaptic neurexin-neuroligin interactions?

Structure. 2021 Jul 1;29(7):635-637. doi: 10.1016/j.str.2021.06.011.

Authors

Juan J Ramirez¹, Dhanesh Sivadasan Bindu², Cagla Eroglu³

Affiliations

¹ Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
² Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
³ Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA; Duke Institute for Brain Sciences (DIBS), Durham, NC 27710, USA; Duke University Regeneration Next Initiative, Durham, NC 27710, USA. Electronic address: cagla.eroglu@duke.edu.

PMID: 34214438
DOI: 10.1016/j.str.2021.06.011

Abstract

Astrocyte-secreted Hevin induces synapse formation by bridging the trans-synaptic organizers, neuroligins and neurexins. In this issue of Structure, Fan et al. (2021) elucidate the structural basis of Hevin's interaction with these molecules and reveal the competitive interplay between Hevin, SPARC, and MDGAs.

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MeSH terms

Cell Adhesion Molecules, Neuronal* / genetics
Synapses*

Substances

Cell Adhesion Molecules, Neuronal