In this paper, a combined pH and impedance sensing system suitable for portable measurements is presented. The sensor outputs are converted directly to frequency or pulse width. The pH sensor is based on a voltage clamp topology that uses charging and discharging capacitors, voltage window comparators, and an SR-Latch to convert the output to frequency. The impedance to frequency sensor is based on current and voltage comparators and an SR-Latch. The pH system based on ISFET transistors is experimentally verified with on chip electrodes while the impedance sensor is characterized with discrete electronic components. The portable system is implemented with two chips and an external multi-electrode array into a portable system. Resistance, capacitance, and pH are experimentally measured using buffer solutions to simulate a water quality monitoring application. The system is implemented in a portable format and all modules, excluding the commercial microprocessor, consume an average power of 56 μW with an area of 0.006 mm 2 using a 180 nm technology.