Secukinumab-induced multiple lentigines in areas of resolved psoriatic plaques: A case report and literature review

Sanquan Zhang; Jingyao Liang; Xin Tian; Xin Zhou; Weiyu Liu; Xiaoyin Chen; Xibao Zhang

doi:10.1111/dth.15048

Secukinumab-induced multiple lentigines in areas of resolved psoriatic plaques: A case report and literature review

Dermatol Ther. 2021 Sep;34(5):e15048. doi: 10.1111/dth.15048. Epub 2021 Jul 7.

Authors

Sanquan Zhang^{1

2}, Jingyao Liang^{1

2}, Xin Tian^{1

2}, Xin Zhou^{1

2}, Weiyu Liu^{1

2}, Xiaoyin Chen^{1

2}, Xibao Zhang^{1

2}

Affiliations

¹ Institute of Dermatology, Guangzhou Medical University, Guangzhou, China.
² Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, China.

PMID: 34212464
DOI: 10.1111/dth.15048

Abstract

Psoriasis is a systemic inflammatory disease commonly associated with postinflammatory hyper- and hypo-pigmentation. Psoriasis-related cytokines such as IL-17 and TNF can contribute to these pigmentation changes by regulating both the growth and pigment production of melanocytes. Here, we present the first reported the case of a patient with a 10-year history of severe psoriasis vulgaris, who developed multiple lentigines in areas of resolved psoriatic plaques during anti-IL-17A antibody secukinumab.

Keywords: IL-17A; multiple lentigines; psoriatic plaques; secukinumab.

Publication types

Case Reports
Review

MeSH terms

Antibodies, Monoclonal, Humanized
Humans
Lentigo*
Pigmentation Disorders*
Psoriasis* / chemically induced
Psoriasis* / diagnosis
Psoriasis* / drug therapy

Substances

Antibodies, Monoclonal, Humanized
secukinumab