Acute Kidney Injury in Pediatric Diabetic Kidney Disease

Federica Piani; Trenton Reinicke; Claudio Borghi; Kalie L Tommerdahl; Gabriel Cara-Fuentes; Richard J Johnson; Petter Bjornstad

doi:10.3389/fped.2021.668033

Acute Kidney Injury in Pediatric Diabetic Kidney Disease

Front Pediatr. 2021 Jun 15:9:668033. doi: 10.3389/fped.2021.668033. eCollection 2021.

Authors

Federica Piani^{1

2

3}, Trenton Reinicke¹, Claudio Borghi³, Kalie L Tommerdahl^{1

2}, Gabriel Cara-Fuentes^{1

4}, Richard J Johnson¹, Petter Bjornstad^{1

2}

Affiliations

¹ Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
² Section of Pediatric Endocrinology, Department of Pediatrics, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
³ Department of Medicine and Surgery Sciences, Alma Mater Studiorum-University of Bologna, Bologna, Italy.
⁴ Section of Pediatric Nephrology, Department of Pediatrics, Children's Hospital Colorado, Aurora, CO, United States.

Abstract

Diabetic kidney disease (DKD) is a common complication of type 1 and 2 diabetes and often presents during adolescence and young adulthood. Given the growing incidence of both type 1 and type 2 diabetes in children and adolescents, DKD represents a significant public health problem. Acute kidney injury (AKI) in youth with diabetes is strongly associated with risk of DKD development. This review will summarize the epidemiology and pathophysiology of AKI in children with diabetes, the relationship between AKI and DKD, and the potential therapeutic interventions. Finally, we will appraise the impact of the recent COVID-19 infection pandemic on AKI in children with diabetes.

Keywords: COVID-19; acute kidney injury; diabetes; diabetic kidney disease; pediatric.

Publication types

Review