Exercise Oscillatory Ventilation in Hypertrophic Cardiomyopathy

Stefanos G Sakellaropoulos; Aaron L Baggish; Michael A Fifer; Gregory D Lewis

doi:10.1016/j.cpcardiol.2021.100911

Exercise Oscillatory Ventilation in Hypertrophic Cardiomyopathy

Curr Probl Cardiol. 2022 May;47(5):100911. doi: 10.1016/j.cpcardiol.2021.100911. Epub 2021 May 29.

Authors

Stefanos G Sakellaropoulos¹, Aaron L Baggish², Michael A Fifer², Gregory D Lewis²

Affiliations

¹ Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA. Electronic address: ssakellaropoulos@mgh.harvard.edu.
² Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

PMID: 34210521
DOI: 10.1016/j.cpcardiol.2021.100911

Abstract

To assess the prevalence and clinical correlates of exercise oscillatory ventilation (EOV) in patients with hypertrophic cardiomyopathy (HCM). Retrospective single-center study. Thirty-six consecutive HCM patients who underwent cardiopulmonary exercise testing. Two patients (5.6%) had EOV. Both patients with peak oxygen consumption (VO₂) less than or equal to 9.1 ml/kg/min had EOV. Left atrial size was greater in patients with EOV. Of the 2 patients in the study population with an abnormal blood pressure response to exercise, 1 had EOV. Both patients with New York Heart Association Class 3 heart failure had EOV. This is the first report of EOV in HCM. EOV is uncommon in patients with HCM. EOV appears to be a marker of disease severity as evidenced by overt heart failure, left atrial enlargement, and low peak VO₂.

Publication types

Review

MeSH terms

Cardiomyopathy, Hypertrophic* / therapy
Exercise Test
Heart Failure*
Humans
Oxygen Consumption / physiology
Prognosis
Pulmonary Ventilation / physiology
Retrospective Studies