Cell-Penetrating Peptides and Transportan

Ülo Langel

doi:10.3390/pharmaceutics13070987

Cell-Penetrating Peptides and Transportan

Pharmaceutics. 2021 Jun 29;13(7):987. doi: 10.3390/pharmaceutics13070987.

Author

Ülo Langel^{1

2}

Affiliations

¹ Department of Biochemistry and Biophysics, Stockholm University, S.Arrheniusv. 16B, Room C466, SE-106 91 Stockholm, Sweden.
² Laboratory of Molecular Biotechnology, Institute of Technology, University of Tartu, Nooruse 1, 50411 Tartu, Estonia.

Abstract

In the most recent 25-30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements. This is followed by a nostalgic journey into the research in my own laboratories, which lead to multiple CPPs, starting from transportan and paving a way to CPP-based therapeutic developments in the delivery of bio-functional materials, such as peptides, proteins, vaccines, oligonucleotides and small molecules, etc.

Keywords: NickFect; PepFect; cell-penetrating peptides; transfection; transportan.

Publication types

Review

Grants and funding

project IUT20-26/Estonian Ministry of Education and Research