Movement as a Positive Modulator of Aging

Int J Mol Sci. 2021 Jun 11;22(12):6278. doi: 10.3390/ijms22126278.

Abstract

The aging of human populations, including those in Europe, is an indisputable fact. The challenge for the future is not simply prolonging human life at any cost or by any means but rather extending self-sufficiency and quality of life. Even in the most advanced societies, the eternal questions remain. Who will take care of the older generations? Will adult children's own circumstances be sufficient to support family members as they age? For a range of complex reasons, including socioeconomic conditions, adult children are often unable or unwilling to assume responsibility for the care of older family members. For this reason, it is imperative that aging adults maintain their independence and self-care for as long as possible. Movement is an important part of self-sufficiency. Moreover, movement has been shown to improve patients' clinical status. At a time when the coronavirus pandemic is disrupting the world, older people are among the most vulnerable. Our paper explores current knowledge and offers insights into the significant benefits of movement for the elderly, including improved immunity. We discuss the biochemical processes of aging and the counteractive effects of exercise and endogenous substances, such as vitamin D.

Keywords: COVID-19; brain-derived neurotrophic factor (BDNF); exercises; geroscience; immunity; irisin; stress; vitamin D.

Publication types

  • Review

MeSH terms

  • Aging*
  • Brain-Derived Neurotrophic Factor / metabolism
  • COVID-19 / immunology
  • COVID-19 / pathology
  • COVID-19 / virology
  • Exercise*
  • Humans
  • Obesity / pathology
  • SARS-CoV-2 / isolation & purification
  • Sarcopenia / pathology
  • Stress, Psychological
  • Vitamin D / administration & dosage

Substances

  • Brain-Derived Neurotrophic Factor
  • Vitamin D