(1) Medicinal use of bryophytes dates to ancient times, but it has always been marginal due to their small size, difficult identification, lack of conspicuous organs which would attract attention (flowers, fruits) and insipid taste of the herb. The earliest testimonies of their medical use come from the 1500s. The interest in medicinal bryophytes diminished considerably in the 1880s, except for Sphagnum spp., which became a source of dressing material. The second half of the 20th century saw the revival of the study of bryophyte chemistry. (2) Historical printed sources from 1616 to 1889 were queried. Bryophyte species found were taxonomically identified and presented against the background of their confirmed properties and ecology. The study was supplemented with historical vs. modern ethnomedicinal data. (3) In 26 publications, 28 species were identified. Modern usage was known for 10 of them. Medicinal properties of 16 species were confirmed. (4) Species of wide geographical distribution range were (or are still being) used in local folk medicines. Historical ethnobiological and ethnopharmaceutical uses of them are sometimes convergent with their confirmed properties, mostly external (as antimicrobial or cytotoxic remedies).
Keywords: bioprospecting of medicinal plants; historical remedies; hornworts; liverworts; mosses.