SARS-CoV-2 and Cytomegalovirus Co-Infections-A Case Series of Critically Ill Patients

Patrícia Moniz; Sérgio Brito; Pedro Póvoa

doi:10.3390/jcm10132792

SARS-CoV-2 and Cytomegalovirus Co-Infections-A Case Series of Critically Ill Patients

J Clin Med. 2021 Jun 25;10(13):2792. doi: 10.3390/jcm10132792.

Authors

Patrícia Moniz¹, Sérgio Brito², Pedro Póvoa^{1

3

4}

Affiliations

¹ Polyvalent Intensive Care Unit, São Francisco Xavier Hospital, Centro Hospitalar de Lisboa Ocidental (CHLO), 449-005 Lisbon, Portugal.
² Internal Medicine Department, São Francisco Xavier Hospital, Centro Hospitalar de Lisboa Ocidental (CHLO), 449-005 Lisbon, Portugal.
³ Nova Medical School, Comprehensive Health Research Centre (CHRC), New University of Lisbon, 449-005 Lisbon, Portugal.
⁴ Center for Clinical Epidemiology and Research Unit of Clinical Epidemiology, Odense University Hospital (OUH), Odense University Hospital, 5000 Odense, Denmark.

Abstract

The SARS-CoV-2 pandemic has placed great strain on the most developed of health care systems, especially in the context of critical care. Although co-infections with cytomegalovirus (CMV) are frequent in the critically ill due to underlying immune suppression of multiple causes, the impact on COVID-19 patients remains unclear. Furthermore, severe COVID-19 has recently been associated with significant immune suppression, and this may in turn impact CMV reactivation, possibly contributing to clinical course. Nevertheless, multiple confounding factors in these patients will certainly challenge upcoming research. The authors present a case series of five patients admitted to the intensive care unit (ICU) in the context of respiratory failure due to severe COVID-19. All patients evolved with CMV reactivation during ICU stay.

Keywords: COVID-19; Cytomegalovirus; SARS-CoV-2; co-infections; critical care.