Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein

Leny Jose; Timra Gilson; Elliot J Androphy; Marsha DeSmet

doi:10.3390/pathogens10070793

Regulation of the Human Papillomavirus Lifecyle through Post-Translational Modifications of the Viral E2 Protein

Pathogens. 2021 Jun 23;10(7):793. doi: 10.3390/pathogens10070793.

Authors

Leny Jose¹, Timra Gilson¹, Elliot J Androphy^{1

2}, Marsha DeSmet¹

Affiliations

¹ Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
² Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Abstract

The human papillomavirus (HPV) is a DNA tumor virus that infects cutaneous and mucosal epithelia where high-risk (HR) HPV infections lead to cervical, oropharyngeal, and anogenital cancers. Worldwide, nearly 5% of all cancers are caused by HR HPV. The viral E2 protein is essential for episomal replication throughout the viral lifecycle. The E2 protein is regulated by phosphorylation, acetylation, sumoylation, and ubiquitination. In this mini-review, we summarize the recent advancements made to identify post translational modifications within E2 and their ability to control viral replication.

Keywords: HPV E2; PTM; replication.

Publication types

Review

Abstract

Publication types

Grants and funding