Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions

Shinya Yano; Toshihiro Mori; Hideki Kubota

doi:10.3390/molecules26123497

Silylated Tag-Assisted Peptide Synthesis: Continuous One-Pot Elongation for the Production of Difficult Peptides under Environmentally Friendly Conditions

Molecules. 2021 Jun 8;26(12):3497. doi: 10.3390/molecules26123497.

Authors

Shinya Yano¹, Toshihiro Mori¹, Hideki Kubota¹

Affiliation

¹ Iwate Drug Synthesis R&D Center, Sekisui Medical Co., Ltd., Iwate 028-7305, Japan.

Abstract

Addition of the silylated tag (STag) enables peptides to be highly soluble in CPME, allowing them to be used at high concentrations in a coupling reaction to enhance reactivity and achieve effective synthesis of sterically hindered peptides. We described the development of a continuous one-pot STag-assisted peptide synthesis platform as a method that provides near-stoichiometric, speedy, environmentally friendly, and scalable peptide synthesis.

Keywords: chemical tag; green chemistry; one-pot; peptide synthesis.

MeSH terms

Chemistry Techniques, Synthetic / methods
Ether / chemistry
Green Chemistry Technology / methods
Peptides / chemical synthesis*

Substances

Peptides
Ether