Small Scorpion-like Peptidomimetics: Potential Broad-Spectrum Membrane Active Antimicrobials without Detectable Resistance

J Med Chem. 2021 Jul 22;64(14):9891-9893. doi: 10.1021/acs.jmedchem.1c01065. Epub 2021 Jul 1.

Abstract

Peptidomimetics have been explored as potential antimicrobial agents against Gram-positive and Gram-negative bacteria. A new scorpion-like peptidomimetic, compound 12, inspired by molecular design in bioengineering, exhibited excellent antimicrobial activity and good selectivity between bacteria and human cells. In addition, compound 12 showed impressive therapeutic efficacy with 99.998% reduction in the in vivo model.

Publication types

  • Introductory Journal Article

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Dose-Response Relationship, Drug
  • Gram-Negative Bacteria / drug effects*
  • Gram-Positive Bacteria / drug effects*
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Peptides / chemical synthesis
  • Peptides / chemistry
  • Peptides / pharmacology*
  • Peptidomimetics / chemical synthesis
  • Peptidomimetics / chemistry
  • Peptidomimetics / pharmacology*
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Peptides
  • Peptidomimetics