Aim: The objective of this research was to investigate the feasibility of transthoracic shear wave elastography in the differentiation of subpleural masses.
Methods: Between December 2019 and November 2020,82 consecutive patients with radiographic evidence (including chest X ray and thoracic computed tomography CT) of single subpleural lesion enrolled in this research. The Young's modulus E (including Emean and Emax) of each lesion was detected, and the Young's modulus E of malignant lesions were compared with those of benign ones. We made diagnoses according to the results of pathology or standard clinical course for at least 3 months. Receiver operating characteristic (ROC) analysis was plotted to determine the cut-off point by maximizing the Youden index.
Results: The Emean and Emax of the benign and malignant group was 34.68 ± 12.12 kPa vs. 53.82 ± 11.95 kPa (p < 0.001), 57.77 ± 14.45 kPa vs. 76.62 ± 17.04 kPa (p < 0.001). The ROC of Emean showed that when the cut-off point was 43.8 kPa, the Youden index (0.53) for distinguishing benign and malignant tumors was the largest (sensitivity 80.4 %, specificity 72.2 %, AUC = 0.848, p < 0.0001). When the cut-off point recommended by Emax ROC was 73.5 kPa, the Youden index (0.44) for distinguishing benign and malignant tumors was the largest (sensitivity 76.1 %, specificity 66.7 %, AUC = 0.780, p < 0.0001).
Conclusions: This study demonstrated that we can employ transthoracic shear wave elastography as a valuable instrument in differentiating benign subpleural lesions from malign ones.
Keywords: Elastography; Lung; SWE; Subpleural; Transthoracic; Ultrasound.
© 2021 The Author(s).