The Biological Function Delineated Across Pan-Cancer Levels Through lncRNA-Based Prognostic Risk Assessment Factors for Pancreatic Cancer

Xudong Tang; Mengyan Zhang; Liang Sun; Fengyan Xu; Xin Peng; Yan Zhang; Ying Deng; Shuliang Wu

doi:10.3389/fcell.2021.694652

The Biological Function Delineated Across Pan-Cancer Levels Through lncRNA-Based Prognostic Risk Assessment Factors for Pancreatic Cancer

Front Cell Dev Biol. 2021 Jun 14:9:694652. doi: 10.3389/fcell.2021.694652. eCollection 2021.

Authors

Xudong Tang¹, Mengyan Zhang², Liang Sun¹, Fengyan Xu¹, Xin Peng³, Yan Zhang², Ying Deng³, Shuliang Wu¹

Affiliations

¹ Department of Human Anatomy, Harbin Medical University, Harbin, China.
² Computational Biology Research Center, School of Life Sciences and Technology, Harbin Institute of Technology, Harbin, China.
³ Department of Emergency Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Abstract

Long non-coding RNAs (lncRNAs) play key roles in tumors and function not only as important molecular markers for cancer prognosis, but also as molecular characteristics at the pan-cancer level. Because of the poor prognosis of pancreatic cancer, accurate assessment of prognosis is a key issue in the development of treatment plans for pancreatic cancer. Here we analyzed pancreatic cancer data from The Cancer Genome Atlas and The Genotype Tissue Expression database using Cox regression and lasso regression in analyses using a combination of the two databases as well as only The Cancer Genome Atlas database (Cancer Genome Atlas Research Network et al., 2013). A prognostic risk score model with significant correlation with pancreatic cancer survival was constructed, and two lncRNAs were investigated. Additional analysis of 33 cancers using the two lncRNAs showed that lncRNA TsPOAP1-AS1 was a prognostic marker of seven cancers, among which pancreatic cancer was the most significant, and lncRNA mi600hg was a prognostic marker of ovarian cancer and pancreatic cancer. LncRNA TsPOAP1-AS1 is associated with clinical stage and tumor mutation burden of some cancers as well as a strong degree of immune infiltration in many cancers, while a strong correlation between lncRNA mi600hg and microsatellite instability was observed in several cancers. The results of this study help further our understanding of the different functions of lncRNAs in cancer and may aid in the clinical application of lncRNAs as prognostic factors for cancer.

Keywords: lncRNA; pan-cancer; pancreatic cancer; prognostic model; survival analysis.