A high-risk gestational trophoblastic neoplasia derived from a complete hydatidiform mole with coexisting fetus identified by short tandem repeats analysis: A case report

Yusuke Taira; Yuko Shimoji; Tadaharu Nakasone; Yoshihisa Arakaki; Tomoko Nakamoto; Tadatsugu Kinjo; Wataru Kudaka; Keiko Mekaru; Yoichi Aoki

doi:10.1016/j.crwh.2021.e00336

A high-risk gestational trophoblastic neoplasia derived from a complete hydatidiform mole with coexisting fetus identified by short tandem repeats analysis: A case report

Case Rep Womens Health. 2021 Jun 17:31:e00336. doi: 10.1016/j.crwh.2021.e00336. eCollection 2021 Jul.

Authors

Yusuke Taira¹, Yuko Shimoji¹, Tadaharu Nakasone¹, Yoshihisa Arakaki¹, Tomoko Nakamoto¹, Tadatsugu Kinjo¹, Wataru Kudaka¹, Keiko Mekaru¹, Yoichi Aoki¹

Affiliation

¹ Department of obstetrics and gynecology, Graduate school of medical science, University of the Ryukyus, Okinawa, Japan.

Abstract

A complete hydatidiform mole coexisting with a fetus (CHMCF) is a rare form of twin pregnancy. High-risk gestational trophoblastic neoplasia (GTN) can occur after a CHMCF pregnancy, although the frequency is low. In cases of GTN, the clinical diagnosis and that based on the International Federation of Gynecology and Obstetrics (FIGO) scoring system can differ. This case report concerns a patient with a choriocarcinoma that was initially diagnosed and treated as a low-risk stage III GTN following a live birth from a CHMCF pregnancy. We used short tandem repeat (STR) analysis to identify the causative pregnancy as the patient's earlier complete hydatidiform mole. Clinicians should anticipate a high-risk GTN when treating persistent trophoblastic disease (PTD) in patients with a non-typical course.

Keywords: Choriocarcinoma; Complete hydatidiform mole coexisting fetus; Gestational trophoblastic neoplasia; Persistent trophoblastic disease; Short tandem repeat.

Publication types

Case Reports