A covalent organic framework-based nanoagent for H2S-activable phototherapy against colon cancer

Jie Feng; Wen-Xiu Ren; Fei Kong; Yu-Bin Dong

doi:10.1039/d1cc02258j

A covalent organic framework-based nanoagent for H₂S-activable phototherapy against colon cancer

Chem Commun (Camb). 2021 Jul 28;57(59):7240-7243. doi: 10.1039/d1cc02258j. Epub 2021 Jun 30.

Authors

Jie Feng¹, Wen-Xiu Ren, Fei Kong, Yu-Bin Dong

Affiliation

¹ College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China. jiefeng@sdnu.edu.cn yubindong@sdnu.edu.cn.

PMID: 34190264
DOI: 10.1039/d1cc02258j

Abstract

Herin, we report a Cu(ii)-porphyrin-derived nanoscale COF, which can be triggered by endogenous H₂S via an intracellular sulfidation reaction to generate a metal-free COF-photosensitizer for PDT against H₂S-enriched colon tumors with controllable singlet oxygen release; meanwhile in situ generated CuS can be synchronously used as a photothermal agent for PTT.

MeSH terms

Animals
Colonic Neoplasms / drug therapy
Colonic Neoplasms / pathology
Colonic Neoplasms / therapy*
Copper / chemistry
HCT116 Cells
Humans
Hydrogen Sulfide / chemistry*
Infrared Rays
Metal-Organic Frameworks / chemistry*
Mice
Microscopy, Confocal
Photosensitizing Agents / chemistry
Photosensitizing Agents / therapeutic use
Phototherapy / methods*
Porphyrins / chemistry
Singlet Oxygen / metabolism
Transplantation, Heterologous

Substances

Metal-Organic Frameworks
Photosensitizing Agents
Porphyrins
Singlet Oxygen
Copper
Hydrogen Sulfide