A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.
Keywords: Trichosporon; fungal infection; immunotherapy; interleukin-7; wound infection.
© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.