The tumor microenvironment consists of noncancerous cells, such as immune cells and fibroblasts, and the proteins produced by these cells as well as the extracellular matrix components in the environment around a tumor. Tumor influences the behavior of the cells present in the surrounding environment, while the cells in the tumor microenvironment modulate the evolution of the tumor. Little is known about the microenvironment of meningioma, the most common benign intracranial tumor. Here, we review the current knowledge of the tumor microenvironment of meningioma and discusses its importance in meningioma tumorigenesis as well as in the designation of novel therapeutic approaches.
Keywords: Cancer; Extracellular matrix; Growth factors; Immune cells; Immune response; Inflammation; Macrophages; Nitric oxide synthase; Peripheral immune tolerance; Stroma; T cells; Tumor angiogenesis apoptosis; Tumor infiltration; Vascular endothelial growth factor.