Abstract
Metal-organic frameworks (MOFs) are proposed to protect a CRISPR-associated enzyme/RNA complex from harsh environments, while the complex can be quickly released from MOFs with high efficiency. Therefore, the application of CRISPR-powered biosensing can be more feasible.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / metabolism*
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Biosensing Techniques*
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CRISPR-Associated Proteins / metabolism*
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CRISPR-Cas Systems / drug effects*
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CRISPR-Cas Systems / genetics
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Coated Materials, Biocompatible / chemistry
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Coated Materials, Biocompatible / pharmacology*
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Endodeoxyribonucleases / metabolism*
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Hydrogen-Ion Concentration
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Metal-Organic Frameworks / chemistry
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Metal-Organic Frameworks / pharmacology*
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Protective Agents / chemistry
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Protective Agents / pharmacology*
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RNA / genetics
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RNA / metabolism
Substances
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Bacterial Proteins
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CRISPR-Associated Proteins
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Coated Materials, Biocompatible
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Metal-Organic Frameworks
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Protective Agents
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RNA
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Cas12a protein
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Endodeoxyribonucleases