Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size

Sherazaan D Ismail; Catherine Riou; Sarah B Joseph; Nancie M Archin; David M Margolis; Alan S Perelson; Tyler Cassidy; Melissa-Rose Abrahams; Matthew Moeser; Olivia D Council; Lyle R McKinnon; Farzana Osman; Quarraisha Abdool Karim; Salim S Abdool Karim; Ronald Swanstrom; Carolyn Williamson; Nigel J Garrett; Wendy A Burgers

doi:10.1093/cid/ciab587

Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size

Clin Infect Dis. 2021 Oct 20;73(8):1528-1531. doi: 10.1093/cid/ciab587.

Authors

Sherazaan D Ismail¹, Catherine Riou^{1

2}, Sarah B Joseph^{3

4}, Nancie M Archin⁵, David M Margolis^{3

5}, Alan S Perelson⁶, Tyler Cassidy⁶, Melissa-Rose Abrahams¹, Matthew Moeser⁴, Olivia D Council⁴, Lyle R McKinnon^{7

8}, Farzana Osman⁷, Quarraisha Abdool Karim^{7

9}, Salim S Abdool Karim^{7

9}, Ronald Swanstrom^{3

10}, Carolyn Williamson^{1

2

7}, Nigel J Garrett^{7

11}, Wendy A Burgers^{1

2}

Affiliations

¹ Division of Medical Virology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
² Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town,South Africa.
³ Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
⁴ Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
⁵ Department of Medicine and UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina,USA.
⁶ Theoretical Biology and Biophysics Group, MS K710, Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
⁷ Centre for the AIDS Programme of Research in South Africa, University of KwaZulu-Natal, Durban, South Africa.
⁸ Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.
⁹ Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
¹⁰ Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
¹¹ Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa.

Abstract

Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8+ T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.

Keywords: HIV-1; T-cell activation; replication-competent virus; reservoir.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Anti-Retroviral Agents / therapeutic use
CD4-Positive T-Lymphocytes
HIV Infections* / drug therapy
HIV-1*
Humans
Viral Load
Virus Latency
Virus Replication

Substances

Anti-Retroviral Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding